SAMe-e is a naturally occuring substance that is produced in the body and regulates many functions in the cells and nervous system. Multi-tasking SAM-e has been found helpful in alleviating depression without side effects. Studies show that SAM-e may reduce stiffness, pain and swelling in arthritic joints. Some research show it helps liver disease and fybromialgia as well. Our 200 mg SAM-e is sourced from premium raw materials. Since it is very hydroscopic (absorbs moisture from its environment), we carefully seal ours in an enteric coating for optimum protection.   View Product Information Sheet (PDF)   The Product Although primarily marketed towards depression, SAM-e assists many health issues, including Osteoarthritis, liver disease, and fybromialgia. Since it absorbs moisture from its environment, we seal it enterically Pharmaceutical grade SAM-e sourced from Italy, the purest, most efficacious and safest source available. We use the SAM-e tosylate disulfate form. This form has been the most extensively utilized form in clinical trials of SAM-e. SAM-e has been shown in numerous studies to support positive mood. SAM-e is essential for normal, healthy liver detoxification. Beneficial for joint health.  Studies show SAM-e participates  in the production of important structural components of healthy connective tissue, including cartilage, ligaments and tendons.  Beneficial for cardiovascular health.  Converting homocysteine to methionine requires SAMe.  SAMe encourages a normal, healthy inflammatory response. Since it absorbs moisture from its environment, we seal ours in a natural enteric coating. Vegetarian Contains no artificial flavors, colors or preservatives; no wheat, gluten, milk, eggs, peanuts, tree nuts, crustacean shellfish or fish. Product Specifications McGuff Item #005853 Count Size: 30 tablets per white HDPE bottle Specification: Vegetarian Tablet One per day dosage Tamper-evident neck band and seal Expiration date to guarantee freshness Sold individually or in cases of 6 and 12 units