Dexamethasone Sodium Phosphate Injection, USP
Dexamethasone Sodium Phosphate Injection, USP is a synthetic adrenocortical steroid supplied as a sterile solution in 4 mg/mL and 10 mg/mL concentrations. It is indicated for a broad range of conditions including endocrine disorders, rheumatic disorders, collagen diseases, dermatologic diseases, allergic states, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema, and diagnostic testing of adrenocortical hyperfunction. The product is administered by intravenous, intramuscular, intra-articular, intralesional, or soft tissue injection depending on the strength and indication.
Key Benefits:
• Rapid onset of action, making it suitable for treatment of acute disorders responsive to adrenocortical steroid therapy
• Potent anti-inflammatory and immunosuppressive activity across disorders of many organ systems
• Available in two concentrations (4 mg/mL and 10 mg/mL) to accommodate multiple routes of administration including IV, IM, intra-articular, intralesional, and soft tissue injection
• At equipotent anti-inflammatory doses, almost completely lacks the sodium-retaining property of hydrocortisone and closely related derivatives
• Indicated for palliative management of leukemias and lymphomas in adults, and acute leukemia of childhood
Dosage & Administration:
For intravenous and intramuscular injection, the initial dosage varies from 0.5 to 9 mg per day depending on the disease being treated; in severe diseases, doses higher than 9 mg may be required. Dosage must be individualized based on the disease and patient response. For cerebral edema, the injection is generally administered initially at 10 mg intravenously, followed by 4 mg every six hours intramuscularly until symptoms subside. For intra-articular, intralesional, and soft tissue injection, the usual dose ranges from 0.2 to 6 mg, with frequency varying from once every three to five days to once every two to three weeks. Multiple dosing regimens exist for specific conditions such as shock, acute allergic disorders, and cerebral edema.
Why Choose Dexamethasone Sodium Phosphate Injection, USP?
Dexamethasone Sodium Phosphate Injection, USP provides rapid-onset corticosteroid therapy across an exceptionally broad range of indications — from acute endocrine and rheumatic disorders to cerebral edema and neoplastic diseases — and is available in two concentrations supporting multiple routes of administration including intravenous, intramuscular, intra-articular, intralesional, and soft tissue injection.
Warnings:
• Serious neurologic events, including spinal cord infarction, paraplegia, quadriplegia, cortical blindness, and stroke — some resulting in death — have been reported with epidural injection of corticosteroids; corticosteroids are not approved for epidural use
• Corticosteroids, including dexamethasone sodium phosphate injection, suppress the immune system and increase the risk of infection with viral, bacterial, fungal, protozoan, or helminthic pathogens; corticosteroid-associated infections can be severe and at times fatal
• Drug-induced secondary adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids; this relative insufficiency may persist for months after discontinuation of therapy and hormone therapy should be reinstituted during stress in that period
Disclaimer: This product description was generated by AI and is for informational purposes only. Please refer to the latest package insert for complete information on indications, contraindications, warnings, and proper use.
