Lidocaine Hydrochloride and Epinephrine Injection
Lidocaine Hydrochloride and Epinephrine Injection is a combination of lidocaine, an amide local anesthetic, and epinephrine, an alpha and beta adrenergic agonist. It is indicated in adult and pediatric patients for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and obstetrical procedures.
Key Benefits:
• Indicated for a broad range of anesthetic procedures including infiltration, peripheral nerve blocks, sympathetic nerve blocks, epidural, and caudal anesthesia
• Available in multiple concentrations (0.5%, 1%, 1.5%, 2%) and presentations including single-dose ampuls, single-dose vials, and multiple-dose vials to support diverse clinical needs
• Epinephrine component allows higher maximum recommended dose (up to 7 mg/kg, not to exceed 500 mg) compared to lidocaine used without epinephrine (4.5 mg/kg, not to exceed 300 mg)
• Approved for use in both adult and pediatric patients across a wide range of procedures
• 1.5% concentration with 1:200,000 epinephrine formulation is specifically recommended as a test dose for epidural and caudal blocks to help detect unintended intravascular or intrathecal injection
Dosage & Administration:
The dosage varies with the anesthetic procedure, area to be anesthetized, vascularity of tissues, depth of anesthesia required, and physical condition of the patient. For normal healthy adults, the maximum recommended dose of Lidocaine Hydrochloride and Epinephrine Injection should not exceed 7 mg/kg body weight and generally should not exceed 500 mg total. For continuous epidural or caudal anesthesia, the maximum recommended dosage should not be administered at intervals of less than 90 minutes. Pediatric dosing is weight- and age-based; for children over 3 years, dosing should not exceed approximately 3.3 mg/kg to 4.4 mg/kg depending on weight and development. The lowest effective concentration and smallest dose producing the desired result should always be used.
Why Choose Lidocaine Hydrochloride and Epinephrine Injection?
This combination product provides both local anesthetic action through lidocaine and vasoconstrictive support through epinephrine, enabling use across a broad spectrum of anesthetic block types — including infiltration, nerve block, epidural, and caudal — in a single formulation available in multiple concentrations and vial presentations, as described in the prescribing information.
Warnings:
• Dose-related toxicity: Cardiovascular and respiratory vital signs and patient's state of consciousness must be monitored after injection; delays in managing toxicity may lead to acidosis, cardiac arrest, and death
• Methemoglobinemia: Cases have been reported with local anesthetic use, with potentially severe consequences including seizures, coma, arrhythmias, and death; patients with glucose-6-phosphate dehydrogenase deficiency, infants under 6 months, and those on oxidizing agents are at increased risk
• Risk of systemic toxicities with unintended intravascular or intrathecal injection: May result in CNS or cardiorespiratory depression, coma, and respiratory arrest; aspirate for blood or cerebrospinal fluid prior to each injection and use a test dose for epidural blocks when feasible
Disclaimer: This product description was generated by AI and is for informational purposes only. Please refer to the latest package insert for complete information on indications,
contraindications, warnings, and proper use.
